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. 2019 Aug;5(4):a003921. doi: 10.1101/mcs.a003921

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© 2019 Quinn et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.

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Figure 7. — The p53 I255del mutant fails to suppress colony formation. Saos-2 cells were transfected with constructs encoding p53 wt (TP53-wt), p53-R175H (TP53-R175H), and selected in medium containing G418. (A) TP53-I255del did not suppress colony formation with respect to TP53-wt, with the number of colonies like that produced with the defective TP53-R175H (P = 0.0026). (B) Corresponding colony numbers for each construct are shown with error bars representing the standard deviation. Data represent two independent experiments, with each experiment comprising two biologic replicates.