Fig. 1.

Body composition and whole-body energy homeostasis. Measurements made in WT and Dysf-deficient BLAJ male mice aged 16 weeks. Body mass (A), lean mass (B), and fat mass (C) assessed by MRI. D: RER averaged over 24 h. Energy expenditure (E), physical activity (F), and food intake (G) assessed over 24 h, n = 12 WT and n = 8 BLAJ mice. H: Food intake in the 90 min after an overnight fast, n = 6 WT and n = 4 BLAJ mice. Data are means ± SEMs. *P < 0.05 versus WT as assessed by two-tailed unpaired t-test (A–D, H). P < 0.05 genotype effect as assessed by two-way repeated-measures ANOVA (F).