Fig. 7.
Genes encoding regulatory proteins of sphingolipid and phospholipid metabolism. A: Expression of key sphingolipid regulatory genes Glb1, Hexb, Cerk, Arsb, Asah1, and Sgpl1 and phospholipid regulatory genes Ptdss1 and Pisd. B: Flowchart describing the observed sphingolipid molecular remodeling. Cer, ceramide; C1P, ceramide-1-phosphate; GalCer, galactosylceramide; GlcCer, glucosylceramide; GM1, monosialotetrahexosylganglioside; GM2, GM2 ganglioside; GM3, GM3 ganglioside; GSL, glycosphingolipid; Hex, hexadecenal; LacCer, lactosylceramide; Spg, sphingosine. Data are means ± SEMs, n = 8 WT and n = 8 BLAJ mice. *P < 0.05 versus WT as assessed by two-tailed unpaired t-test.