Elevation of PPCS in serum, brain, and liver from NPC1 cat model. A: PPCS in sera from control (n = 8), NPC1 carrier (n = 3), and NPC1 (n = 7) cats. Data are presented as mean with SD. P < 0.0001 for NPC1 versus control and NPC carriers. B: PPCS in livers from control (n = 9), NPC1 carrier (n = 5), and NPC1 (n = 5) cats. Data are presented as mean with SD. P < 0.0001 for NPC1 versus control and NPC carriers. C: PPCS in brains from control (n = 10), NPC1 carrier (n = 5), and NPC1 (n = 6) cats. Data are presented as mean with SD. P < 0.0001 for NPC1 versus control and NPC carriers.