TABLE 3.

RRs and 95% CIs for CHD per one SD of CEC and HDL-C

	CECa			HDL-C
	RR	95% CI	P	RR	95% CI	P
Multivariable modelb	0.89	0.77–1.02	0.09	0.68	0.60–0.78	<0.0001
+ LDL	0.84	0.73–0.98	0.02	0.68	0.60–0.78	<0.0001
+ logTG	0.82	0.71–0.95	0.01	0.66	0.58–0.76	<0.0001
+ HDL-C or CEC	1.08	0.85–1.37	0.52	0.68	0.53–0.88	0.004
+ HDL-C or CEC	1.25	1.04–1.50	0.02	0.60	0.51–0.72	<0.0001
+ LDL	1.18	0.98–1.43	0.08	0.60	0.51–0.72	<0.0001
+ logTG	1.08	0.85–1.37	0.52	0.68	0.53–0.88	0.004

SD is 0.14 for CEC and 12.60 for HDL-C and is based on controls only.

^aCEC is calculated as a normalized percentage using the formula: (cpm of ³H-cholesterol in media – cpm of ³H-cholesterol in baseline control)/(cpm of ³H-cholesterol in cells + cpm of ³H-cholesterol in the media) × 100.

^bAdjusted for fasting status, history of diabetes and hypertension, parental CHD before age 60, BMI (<20, 20–24, 25–29, 30–34, ≥35 kg/m²), and alcohol intake (nondrinker, 0.1–4.9 g of alcohol per day (g/day), 5.0–14.9 g/day, 15.0–29.9 g/day, ≥30.0 g/day). Matching factors (cases and controls were matched on age, smoking, and date of blood draw) are incorporated into the analysis using conditional logistic regression.