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. 2019 Aug 1;33(15-16):1083–1094. doi: 10.1101/gad.326868.119

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© 2019 Sun et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — SHP protects mice from CIP. WT (Shp^+/+) and SHP knockout (Shp^−/−) littermates were treated with cerulein to induce CIP. Mice were analyzed for plasma amylase activity (A), pancreatic mRNA levels of inflammatory genes (B), and pancreatic morphology by H&E staining (C) showing edema (asterisks) and necrotic cells (arrows). The percentage of necrotic cells is quantified at the right. Data are represented as mean ± SEM. (*) P < 0.05; (**) P < 0.01; (***) P < 0.001 by two-way ANOVA analysis. n = 3 for vehicle (Veh); n = 5 for CIP mice of each genotype. Representative data of two experiments are shown.