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. 2019 Aug 1;33(15-16):1048–1068. doi: 10.1101/gad.325100.119

Figure 7.

Figure 7.

Lin28b and Igf2bp3 collaborate to activate the fetal transcription program by cobinding cognate mRNAs. (A) Graphical model (not drawn to scale) depicts how Lin28b and Igf2bp3 might collaborate by binding to the 3′ UTR of a cognate mRNA. Note that the stoichiometry of proteins within this RNP complex is not known. (B) A schematic of the molecular circuit in fetal HSPCs regulated by Lin28b and Igf2bp3 (blue represents fetal association) is based on the presented results suggesting that miRNA let-7 repression by Lin28b is only one aspect of this GRN. In adult HSPCs, let-7 (red represents adult association) is predicted to shut down this fetal network. White lines and nodes in the background represent the GRN comprised of thousands of transcripts bound by Lin28b and Igf2bp3. Pax5 and Arid3a are examples of such coregulated targets, which are transcription factors that transmit a molecular cascade from the cytoplasm into the nucleus to mediate a program of gene transcription.