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. 2019 Aug 1;33(15-16):903–935. doi: 10.1101/gad.325050.119

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© 2019 Yu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 11. — Two distinct catalytic subunits, EZH1 and EZH2. (A) Schematic representation depicting the residues/regions that distinguish EZH2 and EZH1. While the SAL, SRM, CXC, and SET domains are well conserved, the SBD, EBD, BAM, SANT1L, and SANT2L domains are less conserved (highlighted in red and pink). Distinct residues within the SRM and SET domains are indicated. The EZH1-specific nucleosome-binding regions (SANT1L, MCSS, and SANT2L) (Son et al. 2013) are poorly conserved with EZH2. (B) The distinct functions of PRC2/EZH2 and PRC2/EZH1 during development are indicated. (C) A summary of the comparsion between PRC2/EZH2 and PRC2/EZH1 activities.