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Reader and writer modules within the PRC2 complex and SUV39H1/2 (yeast CLR4). The “writer” and “reader” modules comprise one protein in the case of SUV39H1/2 (yeast CLR4) (A) but are segregated into two distinct subunits (EZH1/EZH2 and EED, respectively) in the case of PRC2 (B, left). (B, right) PRC2 comprises one of two distinct “writers.” (Middle) EZH1 or EZH2 and can form homodimers or heterodimers, likely providing unknown regulatory roles that are cell type-specific.
