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. 2007 Jan 10;27(2):391–400. doi: 10.1523/JNEUROSCI.3709-06.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/270391-10$15.00/0

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Figure 3. — Effects of multiple spikes and neostigmine on EPSC inhibition. A, In this LAI–MSN pair, a single spike in the LAI significantly reduced the MSN EPSC amplitude for intervals of ∼25 ms (left and middle traces; 10 MSN responses are superimposed for each experiment illustrated in this figure; LAI spikes are truncated). Longer depolarizing current steps elicited 10 spikes and were timed so that the last spike occurred 20–25 ms before the peak of the evoked EPSC (right traces). The MSN EPSC amplitude after 10 LAI spikes was significantly larger than the one after a single spike. B, In a different LAI–MSN pair, a single spike in the LAI significantly reduced MSN EPSC amplitude (interval of 20 ms). In the presence of neostigmine, the MSN EPSC amplitude in the absence of LAI spikes was significantly decreased, and the inhibitory effects of an LAI spike were strongly reduced (from 27 ± 4 to 15 ± 3%). These effects were partially reversed on neostigmine washout.