Table 2.

5-HT, 5-HIAA, NA, and MOPEG concentrations (nanograms per gram of wet tissue) in the striatum, cortex, hypothalamus, hippocampus, and lower brainstem areas of Wt, heterozygous MEN2B/+, and homozygous MEN2B/MEN2B mice

	NA	MOPEG	5-HT	5-HIAA
Striatum
Wt	nd	nd	486 ± 29	252 ± 24
MEN2B/+	nd	nd	518 ± 29	242 ± 20
MEN2B/ MEN2B	nd	nd	509 ± 17	262 ± 21
Cortex
Wt	369 ± 11	7.0 ± 0.67	222 ± 13	32 ± 3
MEN2B/+	382 ± 17	6.7 ± 0.78	240 ± 17	34 ± 3
MEN2B/ MEN2B	360 ± 13	6.5 ± 0.86	235 ± 8	36 ± 3
Hypothalamus
Wt	1731 ± 58	71 ± 1.6	1113 ± 51	244 ± 20
MEN2B/+	1674 ± 77	71 ± 2.3	1072 ± 36	262 ± 23
MEN2B/ MEN2B	1947 ± 58	73 ± 2.5	1166 ± 73	287 ± 55
Hippocampus
Wt	582 ± 19	43.8 ± 2	516 ± 28	164 ± 11
MEN2B/+	571 ± 20	40.7 ± 1	471 ± 12	153 ± 13
MEN2B/ MEN2B	548 ± 14	37.8 ± 2	477 ± 12	119 ± 24
Lower brainstem
Wt	790 ± 29	62 ± 4	611 ± 19	359 ± 38
MEN2B/+	871 ± 27	63 ± 3	622 ± 30	334 ± 29
MEN2B/ MEN2B	1002 ± 53**, a	69 ± 4	658 ± 24	344 ± 23

Data are expressed as means ± SEM. One-way ANOVA and Tukey/Kramer post hoc test were used for statistical analysis.

**p < 0.01 when compared with wild-type mice. n = 6–10 per group. nd, Not detected.

^ap < 0.05 when compared with MEB2B/+ mice.