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. 2007 May 2;27(18):4870–4881. doi: 10.1523/JNEUROSCI.0732-07.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/274870-12$15.00/0

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Figure 8. — WIN55,212,2 inhibits glutamatergic transmission to hypocretin neurons. A, Traces showing the effect of WIN55,212,2 (5 μm) and AM251 (5 μm) on sEPSCs. B, Bar graph showing the effect of WIN55,212,2 and AM251 on sEPSC frequency. C, Traces showing the effect of WIN55,212,2 (5 μm) on mEPSCs in the presence of TTX. D, E, WIN55,212,2 reduces mEPSC frequency (D) but not amplitude (E). F, An example showing the effect of WIN55,212,2 and AM251 on eEPSCs. G, Mean effect of WIN55,212,2 and AM251 on the amplitude of eEPSCs (*p < 0.05, statistically significance). Error bars indicate SEM. Win, WIN55,212,2; Ctrl, control; W/O, washout.