Figure 1.
Density of proliferating cells in the SGZ of the dentate gyrus of the hippocampus. A, Two raters, masked to the intervention, counted BrdU-labeled cells in monkeys randomized to intervention group (control, sham, ECS) and time the animal was killed (immediate-vs delayed-sacrifice). The intraclass correlation coefficient across all counts was 0.97. The density of BrdU-labeled cells in the SGZ was greater in the ECS group than the sham and control groups in the animals killed immediately after the treatment course (t = 6.3; df = 6; p = 0.001) and in animals killed 4 weeks after the completion of the interventions (t = 4.8; df = 2; p = 0.04). B, The density of Ki67-labeled cells in the SGZ was greater in the ECS group than the sham and control groups in the animals killed immediately after the treatment course (t = 3.4; df = 6; p = 0.01) and in animals killed 4 weeks after the completion of the interventions (t = 10.7; df = 2; p = 0.009).