Figure 3.

Inhibition of PP2A and transfection of AktS473A both reversed the memory-impairing effect of CK2α. A, CK2α transfection decreased SGK1 phosphorylation at Ser422, but this effect is reversed by PP2A inhibition through FST administration (n = 7–8 each group). *p < 0.05. A, Compared with control group; b, compared with CK2αWT group. B, CK2α overexpression moderately increased Akt phosphorylation at Ser473, and this effect is slightly potentiated by FST injection. C, A representative illustration showing needle placement and dye distribution in the CA1 area. Scale bar, 400 μm. D, Both PP2A inhibition (by FST injection) and AktS473A transfection reversed the memory-impairing effect of CK2αWT (n = 8–11 each group). FST, Fostriecin. Data are mean ± SEM. Both p < 0.01.