Table 3.

Effects on the brain of deleting apoER2 and Sepp1

	ApoER2−/− mice	Sepp1−/− mice
Migratory defects of neurons	Yes, milda	Nob
Long-term potentiation deficits in hippocampus	Yes, mildc	Yes, severeb
Spatial memory defects	Yes, mildd	Yes, mildb
Associative learning defects	Yesc	Nob
Anxiety changes	Noc	Nob
Balance and coordination defects	Noc	Yes, mildb
Depression of brain selenium concentration	Yes, severe	Yes, severee
Severe neurological dysfunction and death when fed selenium-deficient diet	Yes	Yese

Results are given as comparisons with respective wild-type mice.

^aTrommsdorff et al., 1999.

^bPeters et al., 2006.

^cWeeber et al., 2002.

^dBeffert et al., 2005.

^eHill et al., 2003, 2004.