Table 1.
Demographics and neuropsychological data
| All patients [mean (SD)] | PNFA [mean (SD)] | Semantic dementia [mean (SD)] | LPA [mean (SD)] | Other [mean (SD)] | |
|---|---|---|---|---|---|
| Demographic | |||||
| Age | 64.7 (8.8) | 65.7 (8.4) | 65.2 (7.3) | 66.4 (9.8) | 60.3 (9.8) |
| Gender (M/F) | 29/29 | 6/13 | 10/6 | 7/5 | 6/5 |
| MMSE (max = 30) | 24.2 (4.8) | 25.4 (4.8) | 23.9 (4.48) | 21.8 (5.30) | 24.8 (5.1) |
| Neuropsychological screening | |||||
| WAB fluency (10) | 8.3 (2.2) | 7.6 (3.0) | 8.8 (1.4) | 8.2 (1.5) | 9.0 (1.8) |
| MSE apraxia of speech (7) | 1.2 (2.0) | 2.7 (2.6)c,d | 0 (0) | 1.4 (1.6) | 0.4 (1.2) |
| WAB word recognition total (60) | 57.1 (6.1) | 59.4 (1.2) | 52.2 (9.6)a,b,d | 58.8 (1.0) | |
| Abbreviated BNT (15) | 9.0 (4.8) | 11.9 (2.5) | 3.7 (3.9)a,d | 9.3 (3.0) | 9.0 (1.8) |
| WAB repetition (100) | 87.0 (14.0) | 86.7 (12.3) | 91.3 (8.0) | 78.0 (18.8)e | 91.9 (14.6) |
| Phonemic word generation | 7.0 (4.6) | 5.3 (3.3) | 5.8 (4.5) | 8.7 (5.6) | 9.4 (3.7) |
| Semantic word generation | 8.4 (4.9) | 11.6 (4.8) | 4.6 (3.0)a,b,d | 7.6 (3.7) | 11.0 (5.0) |
| Modified Rey-O delay (17) | 7.7 (4.4) | 9.4 (4.4) | 8.5 (4.2) | 5.7 (4.1) | 7.0 (4.6) |
| CVLT-MS 4-trails correct total (36) | 16.21 (8.1) | 21.4 (7.9)b,c | 11.9 (5.5) | 12.5 (6.2) | 18.1 (9.0) |
| CVLT-MS 10′ free recall (9) | 3.0 (3.2) | 5.7 (3.3)b,c | 1.2 (2.1) | 1.4 (1.6) | 3.0 (2.6) |
| Modified Rey-O copy (17) | 13.9 (4.0) | 12.9 (5.2) | 16.1 (0.9) | 13.4 (2.5) | 12.7 (5.2) |
| Verbal working memory | |||||
| Digits span backward | 3.7 (1.6) | 3.10 (1.32) | 4.18 (1.16) | 3.25 (1.12) | 4.27 (2.41) |
| Sentence comprehension | |||||
| CYCLE-R total score (55) | 47.7 (7.5) | 48.3 (6.4) | 49.4 (7.0) | 44.0 (9.3) | 48.4 (7.7) |
| Type 1 (simple sentences accuracy, %) | 97.6 (4.6) | 98.6 (2.8) | 97.1 (5.4) | 95.6 (6.6) | 98.8 (2.7) |
| Type 2 (non-canonical monopropositional, %) | 83.6 (17.1) | 86.6 (13.2) | 86.2 (15.9) | 73.7 (22.2) | 85.4 (16.9) |
| Type 3 (multiclausal relatives, %) | 81.8 (21.4) | 80.8 (21.2) | 88.1 (19.3) | 74.5 (24.5) | 82.2 (21.4) |
a p < 0.05 versus PNFA
bp < 0.05 versus LPA.
cp < 0.05 versus semantic dementia.
dp < 0.05 versus other dementias.
PNFA, Progressive nonfluent aphasia; MMSE, mini-mental state examination; WAB, western aphasia battery; MSE, motor speech evaluation; CVLT-MS, California verbal learning test-mental status. Italicized numbers indicate statistical significance.