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NMDAR responses summate linearly. A, NMDAR-mediated EPSCs at −50 mV in NBQX (top) or NBQX and nimodipine (NIM; middle) with variable ISIs. Bottom, PPR of EPSC amplitude as a function of ISI in the indicated conditions. B, NMDAR-mediated uEPSCs (top) and ΔG/Rspine (middle) at −50 mV in NBQX with ISI = 50 ms. Bottom, PPR of uEPSC and Δ[Ca]spine amplitude at an ISI of 50 ms. *p < 0.05 compared with unity.
