Figure 1.

MSO causes an acute decrease in synaptic transmission that appears to be independent of glutamate–glutamine cycle inhibition. A, fEPSPs recorded in stratum radiatum of CA1 in rat hippocampal slices (n = 9) are inhibited by MSO (10 mm); however, glutamine (Gln; 4 mm) does not prevent the effect. B, Input–output relationships in slices incubated in MSO (40 mm; n = 11) or control solution (n = 9) for >4 h are not significantly different (p > 0.05 for all fiber volley amplitudes). Representative traces at three fiber volley amplitudes are shown to the right for a control slice (top) and a MSO incubated slice (bottom). FV, Fiber volley. Calibration: 0.5 mV, 10 ms.