Figure 2.

MeAIB produces a rapidly reversible acute depression of synaptic transmission. A, Depression of fEPSPs recorded in stratum radiatum of CA1 is observed after MeAIB (25 mm) application (n = 7). B, Incubation in MeAIB (25 mm) for more than 4 h does not change the input–output curve (control, n = 16; MeAIB, n = 14; p > 0.05 for all fiber volley amplitudes). Representative traces in control slices (top) and MeAIB-incubated slices (bottom) are shown to the right. FV, Fiber volley. Calibration: 0.5 mV, 10 ms.