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. 2007 Aug 22;27(34):9192–9200. doi: 10.1523/JNEUROSCI.1198-07.2007

Figure 4.

Figure 4.

Prolonged incubation in glutamine increases quantal amplitude through a system A-dependent mechanism. A, Quantal amplitude does not change in slices incubated in glutamine (Gln; 4 mm) for <4 h. Cumulative distribution function of amplitudes are not different between glutamine (n = 7) and control slices (n = 9; p > 0.05, Kolmogorov–Smirnov test). Sample recordings from control (top) and glutamine-incubated (bottom) cells. Calibration: 10 pA, 100 ms. B, After more than 4 h of glutamine incubation, quantal amplitude is increased. Cumulative distribution function of amplitudes are significantly increased in glutamine (n = 8) slices over control slices (n = 7; p < 0.05, Kolmogorov–Smirnov test). Sample recordings from control (top) and glutamine-incubated (bottom) cells are shown. Calibration: 10 pA, 100 ms. C, Glutamine enhancement relies on system A transporters. Cumulative distribution function of amplitudes is reduced in slices incubated in glutamine and MeAIB (n = 18) relative to slices incubated in glutamine alone (n = 18; p < 0.05, Kolmogorov–Smirnov test). Sample recordings from glutamine-incubated (top) and glutamine-incubated (bottom) cells. Calibration: 10 pA, 100 ms.