Skip to main content
. 2007 Aug 22;27(34):8989–8998. doi: 10.1523/JNEUROSCI.1830-07.2007

Figure 2.

Figure 2.

Hdh (CAG)150 mice exhibit decreased motor performance compared with WT mice on the accelerating rotarod. Animals were placed on a rotarod accelerating from 4 to 40 rpm within 5 min. Data from 20 weeks (a), 40 weeks (b), 70 weeks (c), and 100 weeks (d) are shown. To determine the rate of task learning, the maximum speed at the time of falling off the rotarod was plotted against the trial number over the first 3 d. Performance over days 4–8 measures motor performance. Note that HET and HOM mice initially learn the rotarod task more rapidly in the first three trials than WT controls at 20 weeks (F (2,23) = 21.2 for effect of trials and F (2,20) = 7.2 for effect of genotype; WT, n = 6; HET, n = 13; HOM, n = 7; p < 0.05). Hdh (CAG)150 mutant mice show no impairment in rotarod performance earlier than 70 weeks. All groups exhibited significant improvement in performance as training progressed; there were no differences between Hdh (CAG)150 mutant mice compared with WT at 40 and 70 weeks (WT, n = 3; HET, n = 9; HOM, n = 10; F (2,19) = 0.175 for effect of genotype; p > 0.05). When mice were examined at 100 weeks, homozygotes exhibited a significant decrease in latency to fall (120.34 ± 19.2 s, p < 0.05 compared with WT, 212.38 ± 27.1 s). Heterozygotes fell after 195.28 ± 22.2 s, which was not significantly different from WT controls (p > 0.05; WT, n = 9; HET, n = 8; HOM, n = 8; F (2,22) = 3.98 for effect of genotype). *p < 0.05. Values are expressed as mean ± SEM seconds.