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Hdh (CAG)150 mice show alterations in D1 and D2 receptor binding as early as 70 weeks. HOM and HET Hdh (CAG)150 mice exhibit significant reductions of striatal D1 (a) and D2 (b) receptor binding compared with WT at 70 weeks. *p < 0.05, significant differences from WT; **p < 0.05, significant differences between HET and WT. All values are expressed as mean pCi/g ± SEM. Ventral Str, Ventral striatum; Dorsal Str, dorsal striatum; SN, substantia nigra.
