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. 2007 Aug 22;27(34):9009–9021. doi: 10.1523/JNEUROSCI.2329-07.2007

Figure 8.

Figure 8.

Cortical hyperexcitability in CGT/(ASA(−/−) mice. A, Representative cortical EEG recordings from CGT/ASA(−/−), ASA(−/−), CGT/ASA(+/+), and ASA(+/+) mice. Note the aberrant discharge episode depicted in an exemplary manner for the CGT/ASA(−/−) mouse. Such discharges were virtually never observed in ASA(+/+) or CGT/ASA(+/+) mice and rarely in ASA(−/−) mice. B, Analysis of the power in the different frequency bands over time for ASA(+/+) mice (left) and CGT/ASA(−/−) mice (right). C, Quantification of the average frequency of recurrent discharges in the different genotypes at 5–6 months of age. Asterisks indicate significant differences (ANOVA with post hoc Bonferroni test). D, Quantification of the average frequency of recurrent discharges in ASA(−/−) and CGT/ASA(−/−) mice at 8–10 weeks of age. The frequency of recurrent discharges was significantly increased in CGT/ASA(−/−) compared with ASA(−/−) mice (ANOVA with post hoc Bonferroni test). E, The frequency of polyspikes in cortical EEG recordings was not significantly different between genotypes at 5–6 months of age (ANOVA with post hoc Bonferroni test). F, The frequency of polyspikes in cortical EEG recordings in ASA(−/−) and CGT/ASA(−/−) mice at 8–10 weeks of age was significantly increased in CGT/ASA(−/−) compared with ASA(−/−) mice (ANOVA with post hoc Bonferroni test). G, Representative example of a recurrent polyspike discharge in a CGT/ASA(−/−) mouse.