Table 4.
Genes significantly altered at 60 d in motorneurons expressing the G93A SOD1
| Probe identification | Gene | Fold change |
|---|---|---|
| Apoptosis | ||
| 1422484_at | Cytochrome c, somatic | 2.00 |
| 1424802_a_at | RIKEN cDNA 3300001P08 gene | 3.88 |
| 1456600_a_at | Ring finger protein 7 | 4.87 |
| 1417815_a_at | Tumor differentially expressed 1 | 2.16 |
| 1416642_a_at | Tumor protein translationally controlled 1 | 2.22 |
| Calcium-binding protein | ||
| 1435884_at | Intersectin 1 (SH3 domain protein 1A) | 2.03 |
| 1456379_x_at | Delta/notch-like EGF-related receptor | 2.56 |
| Cell adhesion | ||
| 1427442_a_at | Amyloid β (A4) precursor protein | 2.88 |
| 1434180_at | Pleckstrin homology domain containing, family C (with FERM domain) member 1 | 2.04 |
| 1416003_at | Claudin 11 | 2.21 |
| 1416473_a_at | Neighbor of Punc E11 | 2.59 |
| 1417749_a_at | Tight junction protein 1 | 2.21 |
| 1438928_x_at | Ninjurin 1 | −2.37 |
| Cell cycle/cell growth | ||
| 1439443_x_at | Transketolase | 2.06 |
| 1422313_a_at | Insulin-like growth factor-binding protein 5 | −2.11 |
| 1437711_x_at | Ornithine decarboxylase | 2.60 |
| 1448005_at | SAM and SH3 domain containing 1 | 2.53 |
| 1454610_at | Septin 7 | 2.76 |
| 1417133_at | Peripheral myelin protein | 5.39 |
| 1419663_at | Osteoglycin | 5.57 |
| Cytoskeletal | ||
| 1456312_x_at | Gelsolin | 2.16 |
| 1428608_at | Myosin light chain, regulatory B | 2.12 |
| 1419738_a_at | Tropomyosin 2, β | −3.24 |
| 1416179_a_at | Radixin | 2.25 |
| 1424800_at | Enabled homolog (Drosophila) | 5.77 |
| Ion transport | ||
| 1451674_at | Solute carrier family 12, member 5 | 2.38 |
| 1448771_a_at | Ferritin heavy chain 1 | 2.79 |
| 1416951_a_at | ATPase, H+ transporting, V1 subunit D | 3.22 |
| 1423890_x_at | ATPase, Na+/K+ transporting, β1 polypeptide | 3.85 |
| Kinases/phosphatases | ||
| 1460315_s_at | TANK-binding kinase 1 | 2.01 |
| 1424827_a_at | Casein kinase 1 α1 | 2.37 |
| 1438562_a_at | Protein tyrosine phosphatase, non-receptor type 2 | 2.66 |
| 1417594_at | G kinase anchoring protein 1 | 2.52 |
| 1434935_at | AP2-associated kinase 1 | 4.75 |
| Metabolism | ||
| 1434465_x_at | Very low-density lipoprotein receptor | 2.10 |
| 1416788_a_at | Isocitrate dehydrogenase 3 (NAD+) γ | −2.02 |
| 1437327_x_at | RIKEN cDNA 2310057D15 gene | 2.13 |
| 1455972_x_at | l-3-Hydroxyacyl-coenzyme A dehydrogenase, short chain | 2.18 |
| 1423804_a_at | Isopentenyl-diphosphate δ isomerase | 2.66 |
| 1434642_at | Dehydrogenase/reductase (SDR family) member 8 | 2.39 |
| 1449686_s_at | Sterol carrier protein 2, liver | 2.46 |
| 1448172_at | Malate dehydrogenase 1, NAD (soluble) | 2.68 |
| 1419063_at | UDP-glucuronosyltransferase 8 | 3.36 |
| 1426689_s_at | Succinate dehydrogenase complex, subunit A, flavoprotein | 2.29 |
| 1452005_at | Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 2.51 |
| Mitochondrial proteins | ||
| 1456580_s_at | ATP synthase, H+ transporting, mitochondrial F1 complex, δ subunit | −2.01 |
| 1449710_s_at | ATP synthase, H+ transporting, mitochondrial F1 complex, α subunit, isoform 1 | 2.68 |
| 1435112_a_at | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d | 2.77 |
| 1416058_s_at | ATP synthase, H+ transporting, mitochondrial F1 complex, γ polypeptide 1 | 5.94 |
| 1424562_a_at | Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | 2.31 |
| 1416300_a_at | Solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 | 4.08 |
| 1433991_x_at | Diazepam-binding inhibitor | 2.13 |
| 1419657_a_at | RIKEN cDNA C330005L02 gene | 4.50 |
| 1455357_x_at | Translocase of outer mitochondrial membrane 20 homolog (yeast) | 2.75 |
| 1428161_a_at | Coiled–coil-helix–coiled–coil-helix domain containing 2 | 3.59 |
| 1423095_s_at | Cereblon | 4.03 |
| mRNA processing | ||
| 1455696_a_at | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 2.49 |
| 1437234_x_at | Heterogeneous nuclear ribonucleoprotein methyltransferase-like 1 (S. cerevisiae) | 2.24 |
| 1460547_a_at | Heterogeneous nuclear ribonucleoprotein K | 2.03 |
| 1433829_a_at | Heterogeneous nuclear ribonucleoprotein A2/B1 | 2.88 |
| 1418562_at | Splicing factor 3b subunit 1 | 2.20 |
| 1437838_x_at | G-rich RNA sequence-binding factor 1 | 2.02 |
| Motor activity | ||
| 1418429_at | Kinesin family member 5B | 2.08 |
| 1423994_at | Kinesin family member 1B | 5.16 |
| 1455434_a_at | Kinectin 1 | 2.57 |
| 1456292_a_at | Vimentin | 3.17 |
| 1436836_x_at | Calponin 3, acidic | 3.95 |
| 1439244_a_at | Trinucleotide repeat containing 6a | 4.80 |
| Nuclear protein | ||
| 1434888_a_at | Matrin 3 | 8.12 |
| 1424251_a_at | Heterogeneous nuclear ribonucleoprotein D-like | 4.46 |
| 1423050_s_at | Heterogeneous nuclear ribonucleoprotein U | 2.56 |
| 1452155_a_at | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 2.29 |
| 1416144_a_at | DEAH (Asp-Glu-Ala-His) box polypeptide 15 | 2.05 |
| 1423292_a_at | Periaxin | 2.70 |
| 1437843_s_at | Nucleoporin-like 1 | 2.37 |
| 1434875_a_at | High-mobility group nucleosomal binding domain 3 | 2.60 |
| 1438940_x_at | High-mobility group nucleosomal binding domain 1 | 2.27 |
| 1417073_a_at | Quaking | 2.72 |
| 1417998_at | Telomerase-binding protein, p23 | 2.35 |
| 1415751_at | Heterochromatin protein 1 | 2.24 |
| 1420477_at | Nucleosome assembly protein 1-like 1 | 2.99 |
| 1448358_s_at | Small nuclear ribonucleoprotein polypeptide G | 2.34 |
| 1417351_a_at | Small nuclear ribonucleoprotein polypeptide A′ | 2.32 |
| 1433834_at | Membrane-associated ring finger (C3HC4) 6 | 3.36 |
| 1439012_a_at | Deoxycytidine kinase | 2.23 |
| 1415991_a_at | Kelch domain containing 3 | −2.69 |
| Oxidoreductase activity | ||
| 1415970_at | Cytochrome c oxidase, subunit VIc | 3.79 |
| 1432263_a_at | Cytochrome c oxidase subunit VIIa polypeptide 2-like | 4.38 |
| 1434435_s_at | Cytochrome c oxidase, subunit XVII assembly protein homolog (yeast) | 3.16 |
| 1416185_a_at | Alcohol dehydrogenase 5 (class III), χ polypeptide | 2.52 |
| 1448610_a_at | Superoxide dismutase 2, mitochondrial | 2.35 |
| 1433603_at | NADH dehydrogenase (ubiquinone) Fe-S protein 6 | 2.74 |
| 1422241_a_at | NADH dehydrogenase (ubiquinone) 1 α subcomplex, 1 | 2.86 |
| 1435235_at | Thioredoxin-like 1 | 2.16 |
| 1437143_a_at | Thioredoxin domain containing 1 | 2.64 |
| Protein binding | ||
| 1449172_a_at | Lin 7 homolog b (Caenorhabditis elegans) | −2.82 |
| 1437455_a_at | B-cell translocation gene 1, antiproliferative | 2.10 |
| 1455286_at | BTB (POZ) domain containing 1 | 2.92 |
| 1424821_at | Nedd4 family interacting protein 1 | 4.73 |
| 1452649_at | Reticulon 4 | 4.87 |
| Protein degradation | ||
| 1434853_x_at | Makorin, ring finger protein, 1 | 2.76 |
| 1455825_s_at | Ligand of numb-protein X 1 | 3.66 |
| 1417202_s_at | Ubiquitin-activating enzyme E1C | 2.34 |
| 1437278_a_at | Ubiquitin-like 1 (sentrin) activating enzyme E1B | 3.09 |
| 1417771_a_at | Proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 2.16 |
| 1448591_at | Cathepsin S | 2.74 |
| 1460698_a_at | Sec11-like 3 (S. cerevisiae) | 3.03 |
| 1437468_x_at | F-box and WD-40 domain protein 11 | 3.30 |
| 1415949_at | Carboxypeptidase E | 7.16 |
| Protein folding | ||
| 1438902_a_at | Heat shock protein 90, α | 2.58 |
| 1418503_at | Heat shock protein 9A | 3.18 |
| 1425993_a_at | Heat shock protein 105 | 2.73 |
| 1433447_x_at | Chaperonin subunit 4 (δ) | 2.59 |
| 1437907_a_at | Tubulin cofactor a | 2.28 |
| Signaling | ||
| 1435495_at | Adenosine A1 receptor | 2.11 |
| 1415849_s_at | Stathmin 1 | 2.19 |
| 1425241_a_at | WD repeat and SOCS box-containing 1 | 2.32 |
| 1418189_s_at | Receptor (calcitonin) activity modifying protein 2 | 8.15 |
| 1416636_at | RAS-homolog enriched in brain | 3.22 |
| 1416426_at | RAB5A, member RAS oncogene family | 3.75 |
| 1419246_s_at | RAB14, member RAS oncogene family | 3.69 |
| 1424902_at | Plexin domain containing 1 | −2.54 |
| 1420196_s_at | TBC1 domain family, member 14 | 2.77 |
| Stress response | ||
| 1437715_x_at | Apurinic/apyrimidinic endonuclease 1 | −2.24 |
| Transcription | ||
| 1435382_at | Necdin | 4.62 |
| 1436153_a_at | Zinc finger, MYND domain containing 11 | 3.13 |
| 1455855_x_at | Heterogeneous nuclear ribonucleoprotein A/B | 2.17 |
| 1452774_at | Heterogeneous nuclear ribonucleoprotein A3 | 2.49 |
| 1451770_s_at | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | 2.27 |
| 1454793_x_at | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 2.64 |
| 1436703_x_at | Small nuclear RNA activating complex, polypeptide 2 | −2.36 |
| 1434434_s_at | Transcription elongation regulator 1 (CA150) | 2.49 |
| 1452193_a_at | Wiskott–Aldrich syndrome-like (human) | 2.02 |
| 1415796_at | DAZ-associated protein 2 | 2.23 |
| 1415820_x_at | Non-POU-domain-containing | 2.10 |
| 1416065_a_at | Ankyrin repeat domain 10 | 2.09 |
| 1438992_x_at | Activating transcription factor 4 | 2.21 |
| 1454758_a_at | Transforming growth factor β1 induced transcript 4 | 2.49 |
| 1456250_x_at | Transforming growth factor β induced | 2.97 |
| 1455222_a_at | Upstream-binding protein 1 | 2.50 |
| 1418324_at | Feminization 1 homolog b (C. elegans) | 2.97 |
| 1435362_at | Forkhead box J3 | 3.20 |
| 1433924_at | Paternally expressed 3 | 4.60 |
| 1437035_x_at | Ring finger protein 14 | 2.69 |
| Translation | ||
| 1416276_a_at | Ribosomal protein S4, X-linked | 3.44 |
| 1418062_at | Eukaryotic translation elongation factor 1 α2 | −2.01 |
| 1448252_a_at | Eukaryotic translation elongation factor 1 β2 | 2.39 |
| 1415723_at | Eukaryotic translation initiation factor 5 | 2.86 |
| 1452285_a_at | Eukaryotic translation initiation factor 3, subunit 5 (ϵ) | 2.49 |
| 1439268_x_at | Eukaryotic translation initiation factor 3 subunit 6 | 2.11 |
| 1448425_at | Eukaryotic translation initiation factor 3 subunit 10 (θ) | 3.25 |
| 1448493_at | Polyadenylate-binding protein-interacting protein 2 | 4.19 |
| 1418883_a_at | PolyA-binding protein cytoplasmic 1 | 2.29 |
| 1423665_a_at | Ribosomal protein L5 | 2.08 |
| 1434377_x_at | Ribosomal protein S6 | 3.40 |
| 1438794_x_at | Ribosomal protein S13 | 2.11 |
| 1454859_a_at | Ribosomal protein L23 | 2.14 |
| 1434854_a_at | Ribosomal protein S10 | 2.32 |
| 1436822_x_at | Ribosomal protein L17 | 2.25 |
| 1450925_a_at | Ribosomal protein S27-like | 2.20 |
| Transport | ||
| 1436737_a_at | Sorbin and SH3 domain containing 1 | 2.57 |
| 1436451_a_at | Transmembrane emp24 domain trafficking protein 2 | 4.23 |
| 1437708_x_at | Vesicle-associated membrane protein 3 | 2.55 |
| 1454697_at | Translocation protein 1 | 2.17 |
| 1449003_a_at | Vesicle transport through interaction with t-SNAREs 1B homolog | 2.25 |
| 1436452_x_at | RIKEN cDNA 1110032D12 gene | 2.31 |
| 1416509_at | SM-11044-binding protein | 2.63 |
| 1419027_s_at | Glycolipid transfer protein | 2.71 |
| 1437723_s_at | Der1-like domain family, member 1 | 2.91 |
| 1439368_a_at | Solute carrier family 9 (sodium/hydrogen exchanger) isoform 3 regulator 2 | −2.15 |
| 1426722_at | Solute carrier family 38, member 2 | 3.98 |
| 1439411_a_at | Exportin 7 | 2.02 |
| Miscellaneous | ||
| 1437341_x_at | Cyclic nucleotide phosphodiesterase 1 | 2.01 |
| 1423792_a_at | Chemokine-like factor superfamily 6 | 2.17 |
| 1448233_at | Prion protein | 3.19 |
| 1416009_at | Tetraspanin 3 | 2.24 |
| 1437211_x_at | ELOVL family member 5, elongation of long chain fatty acids (yeast) | 2.46 |
| 1433723_s_at | Small EDRK-rich factor 2 | 2.74 |
| 1437342_x_at | Pituitary tumor-transforming 1 interacting protein | 2.81 |
| 1423328_at | Ganglioside-induced differentiation-associated-protein 1 | 3.31 |
| 1456741_s_at | Glycoprotein m6a | 3.53 |
| 1423091_a_at | Glycoprotein m6b | 4.76 |
| 1454651_x_at | Myelin basic protein | 2.72 |
| 1423253_at | Myelin protein zero | 7.19 |
| 1451718_at | Proteolipid protein (myelin) 1 | 5.51 |
| 1456174_x_at | N-myc downstream regulated gene 1 | 9.46 |
| 1448108_at | Tumor differentially expressed 2 | 4.72 |
| Unknown | ||
| 1452183_a_at | GTL2, imprinted maternally expressed untranslated mRNA | 3.71 |
| 1448504_a_at | Mus musculus, similar to heterochromatin-like protein 1, clone IMAGE:3493144, mRNA | 6.91 |
| 1453651_a_at | Brain protein 44-like | 2.00 |
| 1423939_a_at | Yip1 interacting factor homolog (S. cerevisiae) | −2.61 |
| 1437345_a_at | Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) | −2.48 |
| 1437991_x_at | RUN and SH3 domain containing 1 | −2.28 |
| 1423251_at | LUC7-like 2 (S. cerevisiae) | 2.08 |
| 1439257_x_at | Ribophorin I | 5.62 |
| 1424071_s_at | cDNA sequence BC018507 | 2.12 |
| 1419291_x_at | Growth arrest specific 5 | 2.45 |
| 1439271_x_at | IK cytokine | 2.52 |
| 1456542_s_at | Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 | 2.73 |
| 1425020_at | UBX domain containing 4, similar to Ubxd4 protein | 4.57 |
| 1433871_at | R3H domain (binds single-stranded nucleic acids) | 2.92 |
| 1448639_a_at | −2.06 | |
| 1450084_s_at | Influenza virus NS1A-binding protein | 3.18 |
| 1455940_x_at | WD repeat domain 6 | 3.27 |
| 1416483_at | Tetratricopeptide repeat domain 3 | 3.46 |
| 1424970_at | Purine-rich element-binding protein G | 3.59 |
| 1433654_at | Meningioma expressed antigen 5 (hyaluronidase) | 4.47 |
| 1428103_at | 3.49 | |
| 1455550_x_at | 2.04 | |
| 1419252_at | 2.25 | |
| 1423758_at | RIKEN cDNA E430034L04 gene | 2.75 |
| 1416911_a_at | RIKEN cDNA 6330407G11 gene | 2.60 |
| 1424707_at | RIKEN cDNA 1110014C03 gene | 2.09 |
| 1448461_a_at | RIKEN cDNA 1500006O09 gene | 2.19 |
| 1416171_at | RIKEN cDNA 2310037I24 gene | 2.27 |
| 1456736_x_at | RIKEN cDNA 5230400G24 gene | 2.28 |
| 1431293_a_at | RIKEN cDNA 1110019C08 gene | 2.42 |
| 1438318_x_at | RIKEN cDNA 1500001L15 gene | 2.91 |
| 1435315_s_at | RIKEN cDNA 2900034E22 gene | 3.35 |
| 1415764_at | RIKEN cDNA 5730454B08 gene | 2.47 |
| 1438171_x_at | RIKEN cDNA 0610012D09 gene | 3.51 |
| 1428288_at | RIKEN cDNA 2310051E17 gene | 3.53 |
| 1450642_at | RIKEN cDNA 3110001I20 gene | 4.78 |
| 1439453_x_at | RIKEN cDNA 1500026D16 gene | −2.84 |
| 1419174_at | RIKEN cDNA 2410004B18 gene | 3.71 |
| 1452167_at | RIKEN cDNA 2810407C02 gene | 4.01 |
| 1434292_at | RIKEN cDNA E130013N09 gene | 2.11 |