Table 5.
Genes significanlty altered at 90 d in motorneurons expressing the G93A SOD1
| Probe identification | Gene | Fold change |
|---|---|---|
| Calcium-binding protein | ||
| 1452363_a_at | ATPase Ca2+ transporting cardiac muscle slow twitch 2 | −2.00 |
| Cell adhesion | ||
| 1456746_a_at | Cd99 antigen-like 2 | 2.96 |
| 1438928_x_at | Ninjurin 1 | 2.01 |
| Cell cycle/cell growth | ||
| 1416427_at | Cyclin I | 2.92 |
| 1438478_a_at | Protein phosphatase 3 catalytic subunit α isoform | 2.19 |
| Cytoskeletal | ||
| 1422520_at | Neurofilament 3 medium | 2.30 |
| 1448553_at | Myosin heavy polypeptide 7 cardiac muscle β | −2.93 |
| Immune response | ||
| 1456108_x_at | Zinc finger protein 179 | −2.15 |
| Ion transport | ||
| 1451071_a_at | ATPase Na+/K+ transporting α1 polypeptide | 4.12 |
| 1423597_at | ATPase aminophospholipid transporter (APLT) class I type 8A member 1 | 2.01 |
| 1421662_a_at | Tumor suppressor candidate 3 | −2.32 |
| 1437143_a_at | Thioredoxin domain containing 1 | −2.09 |
| Kinases/phosphatases | ||
| 1437100_x_at | Proviral integration site 3 | 2.09 |
| 1437690_x_at | Casein kinase 1 δ (Csnk1d) transcript variant 2 mRNA | 2.01 |
| Metabolism | ||
| 1416561_at | Glutamic acid decarboxylase 1 | −2.68 |
| 1415851_a_at | Inosine 5′-phosphate dehydrogenase 2 | 2.02 |
| 1423294_at | Mesoderm specific transcript | 2.50 |
| mRNA processing | ||
| 1449635_at | PRP19/PSO4 homolog (S. cerevisiae) | 2.52 |
| 1415839_a_at | Nucleophosmin 1 | −2.09 |
| 1416150_a_at | Splicing factor arginine/serine-rich 3 (SRp20) | −2.00 |
| 1417351_a_at | Small nuclear ribonucleoprotein polypeptide A′ | −2.02 |
| 1453928_a_at | Sjogren syndrome antigen B | 2.20 |
| Motor activity | ||
| 1448682_at | Dynein cytoplasmic light chain 1 | −2.00 |
| Nuclear proteins | ||
| 1423132_a_at | RIKEN cDNA 5730427N09 gene, similar to TGFβ-inducible nuclear protein 1 (L-name-related LNR42) | 2.45 |
| 1420476_a_at | Nucleosome assembly protein 1-like 1 | 2.30 |
| 1455035_s_at | Nucleolar protein 5A | 2.12 |
| 1448595_a_at | Reduced expression 3 | −2.05 |
| 1419650_at | Zinc finger RNA-binding protein | −2.15 |
| Oxidoreductase activity | ||
| 1422186_s_at | Cytochrome b5 reductase 3 | 2.01 |
| 1435734_x_at | Dihydrouridine synthase 1-like (S. cerevisiae) | 2.03 |
| 1416417_a_at | NADH dehydrogenase (ubiquinone) 1 β subcomplex 7 | 2.00 |
| Protein degradation | ||
| 1426318_at | Serine (or cysteine) peptidase inhibitor clade B member 1b | −2.68 |
| Signaling | ||
| 1424525_at | Gastrin-releasing peptide | −2.02 |
| 1425241_a_at | WD repeat and SOCS box-containing 1 | −2.40 |
| 1421847_at | WD repeat and SOCS box-containing 2 | −3.21 |
| Transcription | ||
| 1418517_at | Iroquois related homeobox 3 (Drosophila) | 4.39 |
| 1428572_at | Brain abundant membrane attached signal protein 1 | 2.03 |
| 1417026_at | Prefoldin 1 | 2.01 |
| Translation | ||
| 1434328_at | Ribosomal protein L15, similar to ribosomal protein L15 | −2.30 |
| 1416520_x_at | Ribosomal protein L36 | 2.20 |
| 1424635_at | Eukaryotic translation elongation factor 1 α1 | −3.35 |
| Miscellaneous | ||
| 1424902_at | Plexin domain containing 1 | 2.98 |
| Unknown | ||
| 1452597_at | RIKEN cDNA 2310061C15 gene | 2.03 |
| 1437345_a_at | Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) | 2.10 |
| 1416655_at | C1GALT1-specific chaperone 1 | −2.02 |
| 1418710_at | CD59a antigen | 2.04 |
| 1453207_at | Hypothetical gene LOC554362 | 2.95 |
| 1433786_x_at | Small EDRK-rich factor 2 | 2.06 |
| 1438143_s_at | 2.07 | |
| 1460709_a_at | HLA-B-associated transcript 5 | 2.30 |