Table 6.
Genes significantly altered at 120 d in motorneurons expressing the G93A SOD1
| Probe identification | Gene | Fold change | |
|---|---|---|---|
| Apoptosis | |||
| 1422484_at | Cytochrome c somatic | −2.51 | |
| 1423534_at | Programmed cell death 2 | −2.25 | |
| 1415910_s_at | Cytokine induced apoptosis inhibitor 1 | −2.48 | |
| 1456071_a_at | NADH dehydrogenase (ubiquinone) Fe-S protein 6 | −2.08 | |
| 1454690_at | Inhibitor of κB kinase γ | −2.16 | |
| 1417516_at | DNA-damage inducible transcript 3 | 3.24 | |
| 1417346_at | PYD and CARD domain containing | 2.44 | |
| Calcium binding | |||
| 1438629_x_at | Granulin | 2.24 | |
| Cell adhesion | |||
| 1456014_s_at | cDNA sequence BC032204 | 4.05 | |
| 1437463_x_at | Transforming growth factor, β induced | 2.18 | |
| 1456133_x_at | Integrin β5 | 3.49 | |
| 1438677_at | Plakophilin 4 | 2.98 | |
| Cell cycle/cell growth | |||
| 1452056_s_at | Protein phosphatase 3 catalytic subunit α isoform | −2.08 | |
| 1436994_a_at | Histone 1 H1c | −2.05 | |
| 1438647_x_at | Centrin 2 | −2.43 | |
| 1439413_x_at | Mortality factor 4-like 2 | −3.28 | |
| 1416427_at | Cyclin I | 2.12 | |
| 1455956_x_at | Cyclin D2 | 3.50 | |
| 1423622_a_at | Cyclin L1 | 2.05 | |
| 1435372_a_at | Proliferation-associated 2G4 | 2.08 | |
| Cytoskeletal | |||
| 1418884_x_at | Tubulin, α1 | −2.47 | |
| 1448991_a_at | Internexin neuronal intermediate filament protein α | 2.7 | |
| 1450732_a_at | Bicaudal D homolog 2 (Drosophila) | 3.31 | |
| Immunity | |||
| 1418021_at | Complement component 4 (within H-2S) | 4.14 | |
| 1437726_x_at | Complement component 1 q subcomponent β polypeptide | 5.25 | |
| 1422903_at | Lymphocyte antigen 86 | 3.36 | |
| 1426808_at | Lectin, galactose binding, soluble 3 | 11.03 | |
| 1439426_x_at | P lysozyme structural | 4.80 | |
| 1423547_at | Lysozyme | 4.48 | |
| 1419873_s_at | Colony stimulating factor 1 receptor | 4.38 | |
| Ion transport | |||
| 1451071_a_at | ATPase, Na+/K+ transporting, α1 polypeptide | −11.03 | |
| 1438578_a_at | RIKEN cDNA 1110056N09 gene | −2.21 | |
| 1426432_a_at | Solute carrier family 4 (anion exchanger), member 4 | 3.35 | |
| 1422557_s_at | Metallothionein 1 | 4.29 | |
| Kinases/phosphatases | |||
| 1422619_at | Phosphatidic acid phosphatase 2a | −3.06 | |
| 1451982_at | Mitogen activated protein kinase kinase 4 | −2.57 | |
| 1436684_a_at | RIO kinase 2 (yeast) | −2.07 | |
| 1424470_a_at | Rap guanine nucleotide exchange factor (GEF) 3 | 3.00 | |
| Metabolism | |||
| 1423804_a_at | Isopentenyl-diphosphate δ isomerase | −4.91 | |
| 1416939_at | Pyrophosphatase | −3.91 | |
| 1424425_a_at | Methylthioadenosine phosphorylase | −3.57 | |
| 1426511_at | Sushi domain containing 2 | −2.61 | |
| 1452005_at | Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | −2.38 | |
| 1423564_a_at | Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase | −2.51 | |
| 1448172_at | Malate dehydrogenase 1, NAD (soluble) | −2.93 | |
| 1451537_at | Chitinase 3-like 1 | 2.06 | |
| 1455084_x_at | Serine hydroxymethyl transferase 2 (mitochondrial) | 2.32 | |
| 1424714_at | Aldolase 3, C isoform | 2.71 | |
| 1437874_s_at | Hexosaminidase B | 3.01 | |
| 1449024_a_at | Hexosaminidase A | 2.23 | |
| Motor activity | |||
| 1456292_a_at | Vimentin | 9.58 | |
| 1423995_at | Kinesin family member 1B | 3.72 | |
| 1448682_at | Dynein, cytoplasmic, light chain 1 | −2.61 | |
| 1450053_at | RIKEN cDNA 1500031M22 gene | −3.27 | |
| mRNA processing | |||
| 1451294_s_at | Small nuclear ribonucleoprotein E | −2.20 | |
| 1423758_at | RIKEN cDNA E430034L04 gene | −3.05 | |
| Nuclear protein | |||
| 1456055_x_at | Polymerase (DNA directed), δ1, catalytic subunit | 2.34 | |
| 1424922_a_at | Bromodomain containing 4 | 2.83 | |
| 1423455_at | Prothymosin α | 2.22 | |
| 1456108_x_at | Zinc finger protein 179 | −2.87 | |
| Oxireductase activity | |||
| 1423035_s_at | Thioredoxin-like 5 | −2.67 | |
| 1415970_at | Cytochrome c oxidase, subunit VIc | −3.14 | |
| 1422241_a_at | NADH dehydrogenase (ubiquinone) 1, α subcomplex, 1 | −2.63 | |
| 1428160_at | NADH dehydrogenase (ubiquinone) 1, α/β subcomplex, 1 | −3.17 | |
| Protein binding | |||
| 1417980_a_at | Insulin-induced gene 2 | −2.30 | |
| 1418412_at | Tumor protein D52-like 1 | −3.40 | |
| Protein degradation | |||
| 1437901_a_at | Vacuolar protein sorting 41 (yeast) | 2.07 | |
| 1417869_s_at | Cathepsin Z | 3.24 | |
| 1427718_a_at | Transformed mouse 3T3 cell double minute 2 | 2.07 | |
| 1417490_at | Cathepsin B | 2.04 | |
| 1456094_at | Ubiquitin-specific protease 36 (11 in man) | 2.79 | |
| 1437714_x_at | Ubiquitin-specific peptidase 14 | −4.27 | |
| 1455825_s_at | Ligand of numb-protein X 1 | −4.53 | |
| 1415688_at | Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) | −2.45 | |
| Signaling | |||
| 1437502_x_at | CD24a antigen | −4.98 | |
| 1423287_at | Cerebellin 1 precursor protein | −3.31 | |
| 1438839_a_at | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ϵ polypeptide | −3.01 | |
| 1420829_a_at | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, θ polypeptide | −3.05 | |
| 1419945_s_at | RAB2, member RAS oncogene family | −2.36 | |
| 1436736_x_at | DNA segment, human D4S114 | −2.88 | |
| 1419811_at | DNA segment, Chr 16, Wayne State University 65, expressed | −2.72 | |
| 1455462_at | Adenylate cyclase 2 | −2.59 | |
| 1419100_at | Serine (or cysteine) proteinase inhibitor, clade A, member 3N | 3.39 | |
| 1450792_at | TYRO protein tyrosine kinase-binding protein | 5.41 | |
| 1460218_at | CD52 antigen | 2.26 | |
| 1424780_a_at | DNA segment Chr 10 University of California at Los Angeles 1 | 3.45 | |
| 1418457_at | Chemokine (C-X-C motif) ligand 14 | 2.78 | |
| 1456212_x_at | Suppressor of cytokine signaling 3 | 2.01 | |
| 1425639_at | Centaurin, α2 | 3.02 | |
| 1418892_at | Ras homolog gene family, member J | 3.60 | |
| 1433757_a_at | Nischarin | 2.36 | |
| 1434020_at | PDGFA-associated protein 1 | 2.30 | |
| 1438403_s_at | Receptor (calcitonin) activity modifying protein 2 | 4.59 | |
| 1439079_a_at | Erbb2 interacting protein | 3.14 | |
| Stress response | |||
| 1416129_at | ERBB receptor feedback inhibitor 1 | −3.09 | |
| 1430979_a_at | Peroxiredoxin 2 | −2.32 | |
| 1416480_a_at | Hypoxia-induced gene 1 | −2.13 | |
| Transcription | |||
| 1418624_at | Nuclease-sensitive element-binding protein 1 | 2.84 | |
| 1415923_at | Necdin | −3.02 | |
| 1427914_a_at | Transcription elongation factor B (SIII), polypeptide 1 | −2.96 | |
| 1425742_a_at | Transforming growth factor β1 induced transcript 4 | −5.96 | |
| 1438250_s_at | TAF9 RNA polymerase II, TATA box-binding protein (TBP)-associated factor | −3.09 | |
| 1433552_a_at | Polymerase (RNA) II (DNA directed) polypeptide B | −3.22 | |
| 1449648_s_at | RNA polymerase 1-1 | −2.23 | |
| 1421292_a_at | RIKEN cDNA A730008L03 gene | −2.14 | |
| Transferase activity | |||
| 1451969_s_at | ADP-ribosyltransferase (NAD+, poly ADP-ribose polymerase)-like 3 | 2.52 | |
| Translation | |||
| 1423220_at | Eukaryotic translation initiation factor 4E | −2.13 | |
| 1415859_at | Eukaryotic translation initiation factor 3, subunit 8 | 3.04 | |
| Transport | |||
| 1450888_at | N-ethylmaleimide-sensitive fusion protein attachment protein β | 2.60 | |
| 1417248_at | ralA-binding protein 1 | 2.40 | |
| 1433774_x_at | Component of oligomeric golgi complex 1 | 2.19 | |
| 1437843_s_at | Nucleoporin-like 1 (Nupl1) mRNA | −3.29 | |
| 1428502_at | ARP6 actin-related protein 6 homolog (yeast) | −2.19 | |
| 1436451_a_at | Transmembrane emp24 domain trafficking protein 2 | −2.99 | |
| Miscellaneous | |||
| 1456438_x_at | Ribophorin I | −3.46 | |
| 1421662_a_at | Tumor suppressor candidate 3 | −2.72 | |
| 1424902_at | Plexin domain containing 1 | −3.04 | |
| 1427351_s_at | Ig heavy chain 6 (heavy chain of IgM) | −5.95 | |
| 1417126_a_at | RIKEN cDNA 3110001N18 gene | −3.23 | |
| 1438178_x_at | ATPase family AAA domain containing 3A | 2.25 | |
| Unknown | |||
| 1436342_a_at | DNA segment Chr 19 ERATO Doi 721 expressed | 5.02 | |
| 1433935_at | Expressed sequence AU020206 | 2.32 | |
| 1418188_a_at | Metastasis-associated lung adenocarcinoma transcript 1 (non-coding RNA) | 2.86 | |
| 1448793_a_at | Syndecan 4 | 6.18 | |
| 1436905_x_at | Lysosomal-associated protein transmembrane 5 | 4.75 | |
| 1424607_a_at | Xanthine dehydrogenase | 3.52 | |
| 1451132_at | Pre-B-cell leukemia transcription factor interacting protein 1 | 2.66 | |
| 1424468_s_at | Pleckstrin homology-like domain, family B, member 1 | 2.16 | |
| 1456319_at | EST X83313 | 7.39 | |
| 1436362_x_at | 2.21 | ||
| 1438069_a_at | RNA-binding motif protein 5 | 2.43 | |
| 1435137_s_at | RIKEN cDNA 1200015M12 gene | 2.37 | |
| 1422861_s_at | RIKEN cDNA 1110001A05 gene | 2.65 | |
| 1451640_a_at | RIKEN cDNA 1500011J06 gene | 2.81 | |
| 1448882_at | RIKEN cDNA 0610009E20 gene | −2.49 | |
| 1450770_at | RIKEN cDNA 3632451O06 gene | −2.74 | |
| 1450904_at | RIKEN cDNA 0610041E09 gene | −2.35 | |
| 1427113_s_at | RIKEN cDNA 2700049H19 gene | −2.48 | |
| 1448179_at | Upregulated during skeletal muscle growth 5 | −3.22 | |
| 1455155_at | cDNA sequence BC040823 | −2.93 | |
| 1434057_at | Similar to NADH dehydrogenase (LOC230075), mRNA | −2.16 | |
| 1418101_a_at | Reticulon 3 | −2.90 | |
| 1423608_at | Integral membrane protein 2A | −3.52 |
PDGFA, Platelet-derived growth factor α.