Figure 2.
Electrical interactions between SWNTs and neurons. A, Spontaneous activity recorded from a 12 d cultured neuron, under current-clamp (top trace) or voltage-clamp (bottom trace) configurations. B, Sketch of the recording chamber. Tracings, Current steps elicited by SWNT stimulation recorded from a patch-clamped neuron (left) or in control-glass preparation (middle) or in SWNTs before sealing to a cell (right). C, Top, Current responses to 400-ms-long SWNT stimuli in a voltage-clamped neuron, summarized in the plot (0.2 V bins; n = 5). Bottom, Current responses in a voltage-clamped neuron elicited via the patch pipette by a step protocol, summarized in the plot (20 mV bins; n = 5). D, Postsynaptic events evoked via SWNT stimulation (*) and recorded under voltage-clamp (bottom) or current-clamp (top) configurations. E, Spontaneous patterned activity and SWNT stimulation. Note that similar waveforms could be evoked via SWNT stimuli (*). Bottom, Single evoked and spontaneous events, as indicated by bars.