Figure 5.

Quantitation of CISH signals in neurons of the entorhinal cortex in both control and AD groups. AD cases compared with controls show the same percentage of cells without or with one spot, but a shift of neurons from two spots toward three and four spots. Statistics were performed for control versus AD groups. Mean values ± SEM are shown. ***p ≤ 0.001; **p ≤ 0.01, Student's t test. In validation experiments, the probe was applied to a proliferating culture of HeLa cells and to PFA-fixed lymphocytes pretreated identically to brain slices.