Figure 6.

A, Frequency distribution of single-neuron DNA content determined by PCR amplification of alu repeats in both control and AD groups. Shift toward higher DNA content in AD cases compared with controls and appearance of a second peak displaying a doubled DNA content are shown (i.e., tetraploid neurons). B, PI integral histograms of single-neuron DNA content obtained by SBC. Each case is represented by a single graph. Similarly to the PCR data, a shift toward a higher DNA content is observed in AD.