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. 2007 Jun 27;27(26):6914–6922. doi: 10.1523/JNEUROSCI.1569-07.2007

Figure 6.

Figure 6.

Administration of EUK-189 inhibits increased activation of the JNK signaling pathway elicited by combined paraquat and iron in SNpc versus paraquat alone. A, B, Phospho-JNK (A) and phospho-c-Jun (green; B) localized (yellow) within TH-positive SNpc neurons (red). 4′,6-Diamidino-2-phenylindole (blue) was used to counterstain nuclei. Original magnification, 10×. C, D, Representative higher-magnification images demonstrating localization of phospho-JNK (C) and phospho-c-Jun (green; D) within dopaminergic neurons (red; arrow). 4′,6-Diamidino-2-phenylindole (blue) was used to counterstain nuclei. Original magnification, 100×. E, F, Quantitative analysis of double labeling of TH with phospho-JNK (E) and phospho-c-Jun (F). Purple bars, Saline plus saline; green bars, neonatal iron fed plus saline; yellow bars, saline plus paraquat; black bars, neonatal iron fed plus paraquat. Error bars indicate mean ± SEM. n = 3. #p < 0.01, significantly from saline plus saline plus vehicle group; *p < 0.05, significantly from saline plus paraquat plus vehicle group; ##p < 0.001, significantly from saline plus paraquat plus vehicle group; **p < 0.001, significantly from neonatal iron fed plus paraquat plus vehicle group.