Figure 7.
DA increases backpropagation of signals into dendrites. A, Calcium imaging of the backpropagation of APs was used as an initial index of dendritic signal propagation. DA enhanced this signal along the apical dendrite. Line trace color corresponds to the color of the box at a location on the dendrite. B, DA increased the amplitude of the signal along the entire extent of the apical dendrite examined. The effectiveness of DA on dendritic signals (percentage change) was greater at dendritic sites further from the soma (right). C, Similar to the effects of DA on EPSPs summation and INa, the effects of DA on the dendritic signal was mimicked by the DA D2 agonist quinpirole (10 μm), whereas the opposite effect was seen after application of the DA D1 agonist SKF81297 (10 μm).