Figure 6.

Normalization of basal synaptic transmission in the CA1 region of TNR-deficient mice by pretreatment of slices with the blocker of L-type Ca²⁺ channels nifedipine (1 μm) or the inhibitor of protein phosphatases calyculin A (1 μm). A, B, Stimulus–response curves in TNR−/− mice are above those in TNR+/+ mice in control untreated slices (A) and after treatment with the NMDA receptor antagonist APV (50 μm) (B) (*p < 0.05; **p < 0.01). C, D, There is no difference between genotypes after treatment with nifedipine (C) or calyculin A (D).