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. 2007 Apr 18;27(16):4385–4395. doi: 10.1523/JNEUROSCI.0055-07.2007

Figure 7.

Figure 7.

DPA reduces conformationally altered and phosphorylated tau in 3xTg-AD mice after dietary supplementation. a, DAB staining with MC1 shows conformationally altered tau immunoreactivity in 40 μm sections from 3 month diet-treated mice (control diet, DHA diet, and DHA–DPA diet). The hippocampus region is shown (magnification, 5×). DAB tau immunoreactivity was elevated in cell bodies of the hippocampus. b, Quantification of a. c, Steady-state levels of phospho-tau epitopes from 9 month PUFA-treated 3xTg-AD mice. d, Steady-state levels of putative tau kinases from 9 month PUFA-treated 3xTg-AD mice. e, Quantification of protein blots from c and d shown normalized to β-actin levels as a loading control. The asterisk denotes significance (p < 0.05). Error bars indicate SEM.