Figure 3.
AELO11207 attenuates MPTP-induced dopamine depletion. A–C, Striatal dopamine levels in C57BL/6 mice 7 d after injection of MPTP (15 mg/kg × 3, s.c., 24 h intervals) alone or in the presence of varying doses (5, 10, 15, or 25 mg/kg, s.c, 1 h before MPTP and daily thereafter for total 3 d) of AEOL11207 (A), after varying injection times (15 mg/kg, s.c., 1 h before MPTP and daily thereafter for a total of 2, 3, or 5 times) of AEOL11207 (B), or after different administration routes (C). Error bars represent mean + SEM. *p < 0.01 versus control; #p < 0.05 versus MPTP; one-way ANOVA; n = 6 mice per group.