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. 2007 Apr 18;27(16):4492–4496. doi: 10.1523/JNEUROSCI.4932-06.2007

Figure 1.

Figure 1.

β-Alanine-induced activation of MrgD strongly inhibits KCNQ2/3 currents in CHO cells. A, Typical step depolarization voltage protocol used to elicit activation of KCNQ2/3 currents. B, Sample sweeps before (1) and ∼1 min into (2) β-alanine (100 μm) exposure. C, Concentration–response relationship for 1, 10, 100, and 500 μm β-alanine. D, Time course of MrgD modulation of KCNQ2/3 currents. Currents were maximally inhibited within ∼1 min of exposure to β-alanine (100 μm) but only when MrgD was present. 1 and 2 refer to times when currents were averaged and displayed in B. Open symbols, Plus MrgD; closed symbols, minus MrgD; open horizontal bar, duration of β-alanine exposure.