Table 1.
Summary of electrophysiological findings
Measurement | Striatal neurons | Neuromuscular junction |
---|---|---|
Spontaneous release (mEPPs) | Unchanged | >10-fold increase in mEPP frequency, independent of calcium |
Evoked synaptic responses | Slow component of IPSC slowed | Slow component of synaptic response slowed |
Amplitude and charge transfer not altered | Amplitude and quantal content decreased | |
Paired-pulse facilitation | Not measured | Decrease in paired-pulse ratio |
High-frequency stimulus trains | Not measured | Desynchronization of vesicle release |
Facilitation of synaptic response (10 or 20 Hz) |
mEPP, Miniature endplate potential.