Figure 4.

Intracellular Ca²⁺ store depletion does not prevent NMDA current inhibition in response to PLC-coupled receptor stimulation. A, B, Traces represent NMDA currents recorded from oocytes expressing NR1/2A (A) or NR1/2B (B) subunits on which EGF or ACh were administered as indicated. Thapsigargin (1–5 μm) was used to pretreat the oocytes for 30–60 min before experiments. C, Bars represent mean ± SE percentage current of current before (control current) or of maximally inhibited current after EGF (100 ng/ml) or ACh (5 μm) application. All sets of means were significantly different (*p < 0.001, t test). Gly, Glycine.