Figure 3.

Interaction of FMRP with mRNAs in synaptoneurosomes. a, The relative amounts of mRNAs were measured from wild-type (wt) and Fmr1 knock-out (ko) synaptoneurosomes by qRT-PCR. No significant difference was observed (unpaired t test, p > 0.05). b, Quantitative measurement of FMRP immunoprecipitated mRNAs from synaptoneurosomes shows that CaMKIIα, GluR1, GluR2, and PSD95 were enriched in the pellet from wild-type synaptoneurosomal preparation compared with that of Fmr1 KO. β-Actin and NR1 mRNAs were not enriched, although present in the preparation. Error bars represent SD. n = 3 for all experiments; *p < 0.05 by Student's t test.