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. 2007 May 16;27(20):5313–5325. doi: 10.1523/JNEUROSCI.3934-06.2007

Figure 4.

Figure 4.

Wnt-7a induces clustering of APC in presynaptic sites in hippocampal neurons. A, Immunofluorescence labeling of hippocampal neurons for p-synapsin (Aa, Ae) or APC (Ab, Af) shows induction in coclustering in the presence of Wnt-7a (Ag, Ah) relative to control (pcDNA) treatment (Ac, Ad) and as indicated in quantification (Ai). B, Double labeling of hippocampal neurons for SV-2 (Ba, Be) and APC (Bb, Bf) shows that Wnt-7a induces coclustering (Bg, Bh) relative to control conditions (Bc, Bd) and as quantified (Bi). C, Double labeling for synaptotagmin (Synaptotag; Ca, Ce) and APC (Cb, Cf) shows induction in coclustering in hippocampal neurons exposed to Wnt-7a (Cg, Ch) relative to controls (Cc, Cd) and as indicated by quantification (Ci). Scale bars, 10 μm. Tables, Colocalization analysis (M) and ICQ values.