Figure 3.

Fbxo2^−/− mice develop age-related hearing loss. a, Representative ABR waveforms from 2-month-old Fbxo2 WT and KO mice, with thresholds of 15 and 50 dB, respectively. b, ABR thresholds of aging, littermate-matched cohorts for WT and Fbxo2^−/− (KO) mice. ABR thresholds for each mouse (crosses) and the group mean (horizontal bars) are designated. Square brackets and “n = 6” indicate that six mice in the 9- to 12-month-old group have no ABR response and were classified as deaf. Statistical significance was determined from the mean ± SD (*p < 0.01; **p < 0.001).