Figure 2.

Increase in agonist-induced currents of AMPA receptors during coexpression of TARPs. Glutamate-induced (300 μm; black columns) and kainate-induced (150 μm; gray columns) responses of AMPA receptors alone and in combination with each of the four TARPs were recorded from Xenopus oocytes in magnesium Ringer's solution. In the top row, GluR1 (A, B) and GluR2 (C, D) are depicted compared with GluR3 (E, F) and GluR4 (G, H) in the bottom row. For quantification, agonist-induced currents of all eight AMPA receptors in coexpression with a TARP were normalized to the responses mediated by the respective AMPA receptor subunit expressed without TARP. Data are shown ± SEM (n = 5–12). *p < 0.05; **p < 0.01; ***p < 0.005 (Student's t test) compared with the respective AMPA receptor subunit expressed without TARP.