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. 2007 Apr 4;27(14):3650–3662. doi: 10.1523/JNEUROSCI.0587-07.2007

Figure 4.

Figure 4.

Analysis of tau species present at 5.5-month-old rTg4510. A, Tau species present in total extracts in 5.5-month-old rTg4510. The abundant ∼55 kDa tau is observed with the E1 antibody without obvious variability between mice. Hyperphosphorylated 64 kDa tau is detected both by E1 and the phospho-epitope-specific AT8 antibody. Both tau170 and tau140 are seen with the E1 antibody, whereas only tau170 is recognized specifically by AT8. Levels of the tau multimers (tau170 and tau140) appear to be variable between different animals. B, Soluble (S1) fraction contains tau ∼55 kDa and tau140, but tau 64 kDa and tau170 are absent. C, Levels of multimers in total extracts exhibit a higher extent of variability across the group (SD of 0.33; 48% of the mean) compared with the levels of multimers in the soluble (S1) fraction (SD of 0.06; 21% of the mean).