Figure 5.

Relationship of tau species and memory impairment (memory index) in 5.5-month-old rTg4510. A, Levels of multimers (tau170 and tau140) in total extracts showed a significant negative correlation with memory index, whereas multimers in the soluble (S1) fraction did not. B, Levels of ∼55 kDa tau in total extracts or in the soluble (S1) fraction did not significantly correlate with memory index. C, Levels of hyperphosphorylated tau ∼64 kDa in total extracts did not exhibit significant correlation with memory index. However, the subpopulation of this species that was extracted into the sarkosyl-insoluble (P3) fraction correlated significantly and negatively with memory index.