Figure 7.

Relationship of tau species and memory index during transgene suppression by doxycycline between 6.5–8 months. A, Levels of multimers in total extracts correlated significantly and negatively with memory index, whereas levels of multimers in the soluble (S1) fraction do not. B, Levels of ∼55 kDa tau in total extracts or in soluble (S1) fraction did not exhibit significant correlation with memory index. C, Levels of hyperphosphorylated tau 64 kDa in total extracts did not significantly correlate with memory, whereas sarkosyl-insoluble 64 kDa tau in P3 fraction does exhibit significant and negative correlation with memory index.