Figure 8.
Tau multimers in 3-month-old rTg4510. A, Levels of multimers in total extracts did not correlate significantly with memory index at 3.5 months. However, removal of an outlier animal with memory index of 8.5 (square) resulted in a significant and negative correlation between levels of tau140 multimers in total extracts and memory index (R2 = 0.45; p = 0.01). B, Levels of multimers in soluble (S1) fraction did not correlate significantly with memory index at 3.5 months, and this analysis is not affected by removing the outlier animal (R2 = 0.11; p = 0.16).