Figure 9.

NFT counts and memory index in 5.5- and 8-month-old rTg4510. A, The number of neurofibrillary tangles in individual rTg4510 mice and memory index displayed a borderline significant negative correlation (R² = 0.33; p = 0.05) in 5.5-month-old rTg4510. B, In 8-month-old rTg4510 mice, the number of neurofibrillary tangles correlated negatively with memory index only in the no-dox cohort (R² = 0.47; p = 0.02), whereas this correlation was completely lost after transgene suppression in the dox cohort (R² = 0.03; p = 0.33). Dox treatment was for 6 weeks from 6.5 to 8 months.