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. 2007 Apr 4;27(14):3663–3676. doi: 10.1523/JNEUROSCI.0448-07.2007

Figure 5.

Figure 5.

DAGL inhibitor prevents endocannabinoid-mediated retrograde signaling in the striatum. A, Sample traces of IPSC (top) and EPSC (bottom) showing the suppression induced by 5 s depolarization (depol.) in vehicle solution (left) and in the presence of THL (right). For EPSC, 50 μm DHPG was supplemented to induce DSE. B, Summary bar graph showing average magnitudes of DSI and DSE after 5 s depolarization in vehicle solution (open columns) and in the presence of THL (filled columns). C, Sample traces showing the effect of 1 μm oxo-M or 50 μm DHPG on IPSCs recorded from MS neurons in the BSA-containing vehicle solution (vehicle) and in the presence of THL (THL). D, Summary bar graph showing the suppression of IPSCs by oxo-M or DHPG. Data are expressed as a percentage of IPSC amplitudes in oxo-M or DHPG relative to the values before oxo-M or DHPG application in the vehicle solution (open columns) and in the presence of THL (filled columns). E, Sample traces showing the effect of oxo-M and DHPG on EPSCs. F, Summary bar graph showing the effect of oxo-M and DHPG on EPSCs. N.S., Not significant. Data are illustrated similarly to D. Calibration: 100 pA, 5 ms. **p < 0.01.