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. 2007 Mar 7;27(10):2457–2467. doi: 10.1523/JNEUROSCI.4239-06.2007

Figure 2.

Figure 2.

Paraquat induces selective loss of subsets of dopaminergic neurons. A, Diagrams of medial and lateral dopaminergic neurons scored. The anterior view is at the top, and the posterior view is at the bottom. B, Average number of neurons per cluster. All scoring of neurons was performed on male w;TH-Gal4;UAS-GFP adults. There was one major paired dopaminergic cluster on the anterior side, PAL (protocerebral anterolateral), and five on the posterior side: PPM1 (unpaired), PPM2 (paired), PPM3 (paired) (protocerebral posterior medial); PPL1 and PPL2 (paired) (protocerebral posterolateral) were counted individually (n = 16–30). PAL and PPL1 were found to be the most sensitive clusters, showing significant loss of DA neurons after 6 h of exposure to 20 mm paraquat. PPM2 and PPM3 clusters started to lose neurons by 12 h of feeding, whereas PPM1 and PPL2 showed significant neuronal loss only at 24 h, when general neuronal damage becomes apparent. *p < 0.05, **p < 0.01, significant differences between paraquat-treated and control neurons in each cluster. Error bars indicate SEM.