Table 3.

Pharmacokinetic parameters for MTIP, CP154526, SSR125543A, and R121919

	Compound/route/dose
	MTIP		CP154526		SSR125543A		R121919
	i.v.	p.o.	i.v.	p.o.	i.v.	p.o.	i.v.	p.o.
	1 mg/kg	10 mg/kg	3 mg/kg	10 mg/kg	3 mg/kg	10 mg/kg	3 mg/kg	10 mg/kg
AUC0– t (ng · h/ml)	3407 ± 277	27,035 ± 3848	568 ± 12	355 ± 44	11,634 ± 2948	9116 ± 1892	154 ± 1	378 ± 25
AUC0–∞ h (ng · h/ml)	3435 ± 275	31,290 (2)	605 ± 16	369 ± 39	12,370 ± 3160	10,118 (2)	164 ± 4	381 ± 26
t ½ (h)	3.9 ± 0.3	3.3 (2)	15.1 ± 2.7	8.2 ± 1.4	10.53 ± 1.84	5.88 (2)	2.8 ± 0.2	1.52 ± 0.07
C max (ng/ml)		2773 ± 148		66.5 ± 3.9		1603 ± 387		77.8 ± 11.1
C 0 (ng/ml)	4714 ± 1952		1274 ± 104		25,744 ± 8468		261 ± 11
t max (h)		2.2 ± 1.0		4 ± 0		4.7 ± 1.8		2 ± 0
Clearance (ml · min−1 · kg−1)	4.9 ± 0.4		82.7 ± 2.1		4.6 ± 1.1		306 ± 7
V d, β (L/kg)	1.7 ± 0.2		114 ± 16		4.2 ± 0.8		75.7 ± 7.2
% Oral bioavailability		91.1		18.3		24.5		69.7

n = 3, except where indicated otherwise in parentheses.