Table 1.

Modifier strains of Drosophila issued from the candidate gene screening for modulators of the lifespan of SCA7 flies

Gene	Function	Simplified genotypea	Effectb
Uba1	Ubiquitin proteasome system	Uba1[UY3010]	Su
Rpn11	Ubiquitin proteasome system	Rpn11[BG01694]	Su
DNAJ-H	Chaperone	PUAS-DNAJ[1]	Su
DIAP1	Caspase pathway	DIAP1[UY1156]	Su
DIAP1	Caspase pathway	th[EY00710]	Su
DIAP1	Caspase pathway	Th[j5C8]	En
ced6	Apoptosis engulfment	ced-6[KG03411a]	Su
HSC70	Unfolded protein response	PUAS-Hsc70 3	Su
Taf10	Transcription complex	Taf10[KG07031]	Su
Tra1	Transcription complex	Nipped-A[NC116]	Su
CBP	Transcriptional cofactor	EP950	En
Rpd3	Transcriptional cofactorc	EP3672	En
mub	RNA-binding proteind	EP3623	En
ATX2	Actin filament formation	ATX2[06490]	Su

^aThe full genotype is given in supplemental Table 2 (available at www.jneurosci.org as supplemental material).

^bEffects were considered significant only if enhancement (En) or suppression (Su) of the lifespan was >15% and p was <0.001.

^cEnhanced the SCA1 phenotype in a previous study (Fernandez-Funez et al., 2000).

^dSuppressed the SCA1 phenotype in a previous study (Fernandez-Funez et al., 2000).